Case Investigation Form

Rabies (ICD 10 Code: A82)

Name of DRU:Address: Type:
II. EXPOSURE HISTORY
Category of Exposure
III. VACINATION HISTORY
IV. CLASSIFICATION AND OUTCOME:
FINAL CLASSFICATION
Case Definition/Classification:

Suspect Case
A person presenting with an acute neurological syndrome (encephalitis) dominated by forms of hyperactivity (furious rabies) or paralytic syndrome (dumb rabies) that progresses towards coma and death, usually by respiratory failure, within 7-10 days after the first symptom if no intensive care is instituted or as diagnosed by attending physician.

Probable Case
Suspect case plus history of contact with suspected or laboratory-confirmed rabid animal.

Confirmed Case
A suspected case that is laboratory confirmed.

Laboratory Confirmation:
  • Detection of rabies viral antigens by direct fluorescent antibody test (FAT) or by ELISA 
    in clinical specimens, preferably brain tissue (collected post mortem).
  • Detection by FAT on skin biopsy (ante mortem).
  • FAT positive after inoculation of brain tissue, saliva or CSF in cell culture, or after intracerebral inoculation in mice or in suckling mice.
  • Detectable rabies-neutralizing antibody titer in the serum or the CSF of an unvaccinated person.
  • Detection of viral nucleic acids by PCR on tissue collected post mortem or intra vitam in a clinical specimen (brain tissue or skin, cornea, urine or saliva).
  • lsolation of rabies virus from clinical specimens and confirmation of rabies viral antigens by direct fluorescent antibody testing.